CeASAR is an internationally-recognized research center that strives to be a leading source of innovative, effective strategies in the prevention, diagnosis, and treatment of substance-related problems in children and adolescents. We have pioneered work in screening and brief intervention strategies for early identification and prevention of substance use problems among adolescents. We have been at the forefront of translating and disseminating the latest neuroscience research findings about the developing adolescent brain and substance use into our substance use prevention strategies for clinicians, educators, parents, and teens. We also partner with neuroscientists in implementing research to generate new knowledge about adolescent substance use effects on brain development, which we feed back into our educational and clinical tools, a unique strength of our partnerships.