Research Assistant: Genetics and Molecular Biology of Brain Tumors
Dr. Christian Badr, Badr Lab, Department of Neurology, Massachusetts General Hospital / Harvard Medical School
fall 2019


Research Assistant wanted to study fatty acid metabolism in brain tumor cancer stem cells. We are seeking volunteer-based Research Assistants to join our group focused on brain tumor research at Massachusetts General Hospital. The lab, which is part of the MGH Neurology Department, is located in Charlestown, MA (149 13th Street, Charlestown, MA 02129). Our lab is focused on studying molecular aspects governing self-renewal and tumor initiation in brain tumor initiating cells and using this knowledge to develop targeted therapies for brain tumors. Some details about current work is provided in our recent manuscript and our lab webpage. Responsibilities: We are seeking highly motivated students looking to gain hands-on experience in molecular biology, cell biology and cancer genetics. The incumbent of this position will receive daily mentorship and will work on studying gene regulation and the molecular biology of brain tumors, particularly in the context of lipid and fatty acid metabolism. Some of the key techniques involved in this research include (1) mammalian tissue culture, including maintenance and propagation of primary patient-derived cancer (stem) cells as well as common laboratory cell lines; (2) RNA or protein isolation from cells. Quantitative RT-PCR on RNA or western blots on proteins; (3) cell based assays such as cell viability, flow cytometry and measurement of bioluminescence or fluorescence; and (4) implantation of tumor cells in mice, optical imaging of tumors and testing of new therapeutics in these mouse models. Requirements and Expectations: Previous experience in molecular biology techniques is desired but not required. Part-time candidates should be able to commit to a minimum of 20 hours/week. To Apply: Interested individuals should email a Resume and a brief description of research interest and career goals to Dr. Christian E. Badr (badr.christian@mgh.harvard.edu). (posted 9/2018)